Myelin basic protein and its diagnostic value in HIV-infected individuals with 4th clinical stage and neuroinfections

It was shown that in HIV-infected patients, pathomorphological changes the white matter form of demyelinization are already observed early stages disease. The most studied marker this process is myelin basic protein can be detected cerebrospinal fluid or serum immediately after acute breakdown.
 aim. To assess diagnostic value content and individuals with 4th clinical stage central nervous system opportunistic infections.
 Materials methods. Using ELISA kit “MBP ELISA” (Ansh Labs, USA), we 53 patients infections depending on its etiology, outcome diseases according to Glasgow coma scale score. As well correlation analysis some laboratory indicators performed.
 Results. We found significantly increased both compared control (p˂0.01), which indicate presence active system. highest registered an unfavourable disease, as death residual neurologic deficit, cerebral toxoplasmosis. had association size lesions magnetic resonance imaging content.
 Conclusions. Myelin detection serve additional quantitative disruption, used along for diagnosis improvement prognosis